Professor Victor Solovyev
+ Work Address:
Department of Computer Science,
Royal Holloway, University of London,
Egham, Surrey TW20 0EX,
United Kingdom
+ Telephone: +44 (0)1784 443673 FAX: +44
(0) 1784 439786
+ Email:(victor@cs.rhul.ac.uk)
Expert in computational
biology and leading author of widely used bioinformatics software. I worked as
Genome annotation Group Leader in Joint Genomic Institute, Lawrence Berkeley
National Lab (2003) and a consultant to several biotechnology/bioinformatics
companies as well as Director of Bioinformatics at EOS Biotechnology
(1999-2002) and leader of Computational Genomics Group at the Sanger Centre,
Cambridge, UK (1997-1999). He also held positions of assistant professor at
Baylor College of Medicine, computational scientist at Amgen, visiting
scientist at Supercomputer Center, Florida State University, visiting professor
at ITBA (Milan, Italy) and group leader at Institute of Cytology and Genetics,
Novosibirsk, Russia. Dr. Solovyev received Ph.D. in computational genetics from
Russian Academy of Sciences in 1985 and M.S. in physics from Novosibirsk State
University in 1978.
Area of
Scientific ihc.uk
terest: Computational Biology
Developing computational methods of statistical analysis of bio-medical data including sequences and structures to discover non-random patterns responsible for their functions: prediction of promoters and splice sites using discriminant analysis, finding bacterial and eukaryotic genes by Hidden Markov Models, fast comparison of genomes, prediction of protein sub-cellular localization using neural networks approaches; fold recognition, modeling protein structure and protein-ligand docking; statistical analysis of expression data with finding disease specific genes; discovery and finding transcription regulation motifs and regulatory networks, developing databases of genomic information, building software pipelines of high-throughput computational analysis of bio-medical data; developing software to support new sequencing technologies (Solexa sequencing machine), SNP detection and transcriptome analysis (with RNASeq data). Application of bioinformatics approaches to potential drug targets discovery, modeling drug response and genetic networks gaining insights into the static and dynamic behavior of complex biological systems.
Member of the Board/Editor of Mathematical Biosciences journal (2008 ¿present)
The leading
author/coauthor of the WWW servers programs:
The
Sanger Centre, Baylor College of Medicine and Softberry Inc. Genefinder
services:
* Fgenesh++ - automatic eukaryotic genome annotation pipeline with
* Fgenesb_annotator - pipeline to annotate new bacterial sequences
with genes, operons, promoter and terminator predictions.
* SELTAG - analysis of EXPRESSION DATA to select drug targets for
disease specific genes
* GenomeExplorer - visualization and interactive work with genome annotation
* FGENESH - HMM based prediction of multiple genes in genomic DNA
* BESTORF - prediction of coding regions and ORFs in mRNA/cDNA/EST sequences
* FGENEH+ - search for Human gene structure with using similar protein
* FGENEH_C - search for Human gene structure with using similar EST/cDNA
* SPL - splice sites identification in genomic sequences
* TSSG/W - recognition of human promoter regions
* SSPAL - prediction of secondary structure using local alignments
* ProtComp - identification of Protein sub-cellular location
* FOLD - recognition of protein fold by using 3D environment characteristics
* SCAN2 - comparison long genomic sequences
* DBSCAN - comparison genomic sequence with a database of genomic sequences
* EST_MAP - fast mapping a SET of mRNA/EST on chromosome sequence
* Prot_MAP - fast mapping a SET of proteins on chromosome sequence
* OligoZip - sequence assembling tools for new generation sequencing
technology
* Transomics ¿ pipeline to map RNAseq data, assemble them into transcripts
and quantify the abundance of these transcripts in particular datasets
* MolQuest - Bioinformatics Toolbox for analysis of biomedical data
Ph.D. Supervised:
* 1. Rogozin I.B. " Theoretical
analysis of the mechanisms of
spontanious and indused mutations"
Institute Cytology and genetics,
Novosibirsk, 1990.
* 2. Salamov A.A. "Computer system for
investigation of globular protein
secondary structure", Institute
Cytology and Genetics,
Novosibirsk,1991.
Author
of more than 100 scientific publications, including 8 monographs,
several
books for university students and the following main publications:
Monographs:
* Solovyev V.V., Salikhova A.K., Lim H.A.
Tertiary structure calculations
of a-helical domains of protein molecules
using the quasispherical
primary approximations. In Biomedical
Modeling and Simulation
(J.Eisenfeld, D.Levin, M.Witten Eds.)
1992, Elsevier Science
Publishers B.V. (North-Holland),
p.201-211.
* Ratner V.A.,Zharkikh A.A,Kolchanov
N.A.,Rodin S.N.,Solovyev V.V.
Shamin V.V. Problems of the theory of
molecular evolution. ( R.I.
Salganik ed.)
"Science",Siberian Branch of the USSR Academy of
Science, Novosibirsk, (Russ) 259 p.
(1985).
* Solovyev V.V. Analysis of functional
sites in pro- and eukaryotic
genes. In "Methods of molecular
genetics and gene engineering" ( R.I.
Salganik ed.) "Science",
Novosibirsk, (Russ.) 154-190, (1990).
* Solovyev V.V et al., 12 paragraphs In
Computer analysis of Genetic
Macromolecules. Structure, Function and
Evolution. (eds. Kolchanov
N.A., Lim H.A.), 1994, World Scientific,
556 p.
* Ratner V.A.,Zharkikh A.A,Kolchanov
N.A.,Rodin S.N.,Solovyev V.V.,
Antonoc A.S. Molecular evolution.
Biomathematics, V 24, Springer,
1996, p.433.
# Solovyev V.V. (2002) Structure,
Properties and Computer Identification of
Eukaryotic genes. In Bioinformatics from
Genomes to Drugs. V.1. Basic
Technologies. (ed. Lengauer T.), p. 59 -
111.
# Solovyev V.V., Shindyalov I.N. (2002) Properties and Prediction
of Protein
Secondary Structure. In
Current Topics in Computational Biology (eds.
T.Jiang, T. Smith, Y. Xu,
M. Zhang), in The MIT Press, p. 201 – 248.
# Solovyev V.V. (2002) Finding genes by computer: probabilistic
and
discriminative
approaches. In Current Topics in Computational Biology (eds.
T.Jiang, T. Smith, Y. Xu,
M. Zhang), in The MIT Press, p. 365-401.
Selected Articles:
The Nasonia Genome Working Group, et al. (2010) Functional and Evolutionary Insights from the Genomes of Three Parasitoid Nasonia Species. Science 327, 343-348. The Bovine Genome Sequencing and Analysis Consortium. (2009) The Genome sequence of taurine cattle: A window to ruminant biology and evolution. Science, 324, 522-528. Mayako Michino et al., (2009) Community-wide assessment of GPCR structure modelling and ligand docking. Nature Reviews Drug Discovery 8, 455-463. Coghlan A. et al. (2008) nGASP - the nematode genome annotation assessment project. BMC Bioinformatics 2008, 9:549. Richards S. et al., (2008) The genome of the model beetle and pest Tribolium castaneum. Nature. 452 (7190), 949-55. Velasco R. et al (2007) A High Quality Draft Consensus Sequence of the Genome of a Heterozygous Grapevine Variety. PLoS ONE 2(12): e1326. Solovyev V.V. (2007) Statistical approaches in Eukaryotic gene prediction. In Handbook of Statistical genetics (eds. Balding D., Cannings C., Bishop M.), Wiley-Interscience; 3 edition, 1616 p.
Weinstock et al. Insights into social insects from the genome of the honey bee Apis mellifer. Nature (2006) , 433, 7114, 931-949.
Solovyev V, Kosarev P, Seledsov I, Vorobyev D. Automatic annotation of eukaryotic genes, pseudogenes and promoters. Genome Biol. 2006,7, Suppl 1: P. 10.1-10.12.
Bajic VB, Brent MR, Brown RH, Frankish A, Harrow J, Ohler U, Solovyev VV, Tan SL. Performance assessment of promoter predictions on ENCODE regions in the EGASP experiment. Genome Biol. 2006, 7, Suppl 1, p. 3.1-3.13.
Shahmuradov I, V. V. Solovyev and A. J. Gammerman (2005) Plant promoter prediction with confidence estimation. Nucleic Acids Research 33(3):1069-1076.
Tyson, G.W., Chapman, J.,
Hugenholtz, P. , Allen, E. , Ram, R.J.*,
Richardson, P., Solovyev, V., Rubin, E. , Rokhsar, D., and Banfield,
J.F. (2004) Community structure and metabolism through reconstruction of microbial genomes
from the environment.
Nature, 428(6978), 37-43.
Grimwood J, Gordon LA, Olsen A, .., Solovyev V., ..., Lukas S. (2004) The DNA sequence and biology of human chromosome 19. Nature, 428(6982), 529-535.
Michael Brudno, Alexander Poliakov, Asaf Salamov3,
Gregory M. Cooper, Arend Sidow, Edward M. Rubin2, Victor Solovyev,
Serafim Batzoglou, Inna Dubchak (2004) Automated Whole-Genome Multiple Alignment of
Rat, Mouse, and Human. Genome Research, 14(4), 685-92.
Hild M, Beckmann B, Haas SA, Koch B, Solovyev V, Busold C, Fellenberg K, Boutros M, Vingron M, Sauer F, Hoheisel JD, Paro R. (2003) An integrated gene annotation and transcriptional profiling approach towards the full gene content of the Drosophila genome. Genome Biol., 5(1):R3. Epub 2003 Dec 22.
Shahmuradov IA, Akbarova YY, Solovyev VV, Aliyev JA. (2003) Abundance of
plastid DNA insertions in nuclear genomes of rice and Arabidopsis. Plant Mol Biol. 52(5): 923-934.
Gordon L, Chervonenkis AY, Gammerman AJ, Shahmuradov IA,
Solovyev VV. (2003)
Sequence alignment kernel for recognition of promoter
regions.
Bioinformatics. 19(15):1964-1971.
Solovyev VV, Shahmuradov IA. (2003) PromH: Promoters identification using orthologous genomic sequences. Nucleic Acids Res. 31(13):3540-3545.
Shahmuradov IA, Gammerman AJ, Hancock JM, Bramley PM, Solovyev VV. (2003) PlantProm: a database of plant promoter sequences. Nucleic Acids Res. 31(1): 114-117.
Schuller CM, Geier B, Fritz A, Salamov A, Seledsov I, Solovyev V, Frishman D. (2002) The pedant human genome database - functional annotation of the human genome. Scientific World Journal. 2 (1 Suppl 2): 82-83.
*Burset
M., Seledtsov I., Solovyev V. (2001) SpliceDB: database of canonical
and
non-canonical mammalian splice sites. Nucleic Acids Res., 29(1), 255-259.
*Salamov
A., Solovyev V. (2000) Ab initio gene finding in Drosophila
genomic
DNA. Genome Res. 10(4), 516-522.
*Burset
M., Seledtsov I., Solovyev V. (2000) Analysis of canonical and non-canonical
splice
sites in mammalian genomes. Nucleic Acids Res., 28(21), 4364-4375.
Filippov
V., Solovyev V., Filippova M., Gill S. (2000) A novel type of RNase
III
family proteins in eukaryotes. Gene, 245(1), 213-221.
*Kolchanov
NA, Ponomarenko MP, Frolov AS, Ananko EA, Kolpakov FA,
Ignatieva
EV, Podkolodnaya OA, Goryachkovskaya TN, Stepanenko IL, Merkulova
TI,
Babenko VV, Ponomarenko YV, Kochetov AV, Podkolodny NL, Vorobiev DV,
Lavryushev
SV, Grigorovich DA, Kondrakhin YV, Milanesi L, Wingender E,
Solovyev
V, Overton GC (1999) Integrated databases and computer systems for
studying
eukaryotic gene expression. Bioinformatics, 15(7-8):669-86
*Solovyev
V.V., Salamov A.A. (1999) INFOGENE: a database of known gene
structures
and predicted genes and proteins in sequences of genome
sequencing
projects. Nucl.Acid Res., 27,248-250.
*Alexandrov
N.N., Solovyev V.V.(1998) Statistical significance of ungapped
sequence
alignment. In Pacific Symposium on Biocomputing'98 (eds. Altman
R.,Dunker
K.,Hunter L., Klein T.), p.463-472.
*Kolchanov
N.A. et al. (1998) GeneExpress: a computer system for
description,
analysis, and recognition of regulatory sequences in
eukaryotic
genome. In Proceedings of the Sixth International Conference on
Intelligent
Systems for Molecular Biology (eds.Gaasterland T. et
al.),95-104
*Agulnik
A.I.,Bishop C.E., Lerner J.L., Agulnik S.I., Solovyev V.V.(1977)
Analysis
of mutation rate in the SMCY/SMCX genes shows that mammalian
evolution
is male driven. Mammalian Genome 8, 134-138.
*Salamov
A.A., Solovyev V.V. (1997) Protein secondary sturcture prediction
using
local alignments. J. Mol.Biol,268,1, 31-36..
*Solovyev
V.V., Salamov A.A. (1997) The Gene-Finder computer tools for
analysis
of human and model organisms genome sequences. In Proceedings of
the
Fifth International Conference on Intelligent Systems for Molecular
Biology
(eds.Rawling C.,Clark D.,Altman R.,Hunter L., Lengauer T.,Wodak
S.),
Halkidiki, Greece, AAAI Press,294-302.
*Salamov
A.A., Solovyev V.V. (1997) Recognition of 3'-end cleavage and
polyadenilation
region of human mRNA precursors. CABIOS 13, 1, 23-28.
*Alexandrov
N., Solovyev V. (1996) Effect of Secondary Structure
Prediction
on Protein Fold Recognition and Database Search. The Seventh
Workshop
on Genome Informatics (GIW96), Tokyo, Japan.
*Kelly
R.L., Solovyeva I., Lyman L.M., Richman R., Solovyev V.V., Kuroda
M.
(1995) Expression of MSL-2 causes assembly of dosage compensation
regulators
on the X chromosomes and female lethality in Drosophila.
Cell,81,867-877.
*Solovyev
V.V., Salamov A.A., Lawrence C.B. (1995) Prediction of human
gene
structure using linear discriminant functions and dynamic programming.
In
Proceedings of the Third International Conference on Intelligent Systems
for
Molecular Biology (eds. Rawling C.,Clark D.,Altman R.,Hunter
L.,Lengauer
T.,Wodak S.), Cambridge,England, AAAI Press,367-375.
*Salamov
A.A., Solovyev V.V. Prediction of protein secondary structure by
combining
nearest-neighbor algorithms and multiple sequence alignments. J.
Mol.Biol.
(1995), 247,1,11-15.
*Solovyev
V.V., Salamov A.A. Predicting a-helix and b-strand segments of
globular
proteins. CABIOS (1994),v.10,6,661-669.
*Solovyev
V.V., Salamov A.A., Lawrence C.B. Predicting internal exons by
oligonucleotide
composition and discriminant analysis of spliceable open
reading
frames. Nucl. Acids Res. (1994) 22,N 24,5156-5163.
*Solovyev
V.V., Salamov A.A., Lawrence C.B. 1994. The prediction of human
exons
by oligonucleotide composition and discriminant analysis of
spliceable
open reading frames. In Proceedings of the Second International
Conference
on Intelligent Systems for Molecular Biology (eds. Altman
R.,Brutlag
D.,Karp P.,Lathrop R.,Searls D.), Stanford,CA, 354-362.
*Lawrence
C.B., Solovyev V.V. Assignment of Position-Specific Error
Probability
to primary DNA Sequence Data. Nucl.Acids Res., 1994, 22,
7,1272-1280.
*Solovyev,V.,
Lawrence,C.B. Prediction of human gene structure using
dynamic
programming and oligonucleotide composition. In: Abstracts of the
4th
annual Keck symposium. Pittsburgh, 47,1993.
*Solovyev
V.V., Streletc V.B., Milanesi L. (1993) Multiple sequence
alignment
based on new approaches of tree construction and sequences
comparison.
Proceedings of the 2-nd International conference on
Bioinformatics,
Supercomputing, and Complex genome analysis. (eds. Lim H.,
Fickett
J., Cantor C., Robbins R.), World Scientific, 419-428.
*Solovyev
V.V. Fractal graphical representation and analysis of DNA and
Protein
sequences. BioSystems, 30, (1993), 137-160.
*Solovyev
V.V., Lawrence C.B. (1993) Identification of Human gene
functional
regions based on oligonucleotide composition. In Proceedings of
First
International conference on Intelligent System for Molecular Biology
(eds.
Hunter L., Searls D., Shalvic J.), Bethesda, 371-379.
*Solovyev
V.V., Makarova K.S. A novel method of protein sequences
classification
based on oligopeptide frequency analysis and its application
to
search for functional sites and to domain localization. CABIOS 1993,
17-24.
*Makarova
K.S., Mazin A.V., Wolf Y.I., Solovyev V.V. "DIROM"- an
experimental
design interactive system for directed muta- genesis and
nucleic
acids engineering. CABIOS 1992,8,425-431.
*Solovyev
V.V., Korolev S.V., Lim H.A. A new approach for the
classification
of functional regions of DNA sequences based on fractal
representation.
1993, Int.J. Genomic. Res.,1,2, 108-127.
*Seledtsov
I.A., Solovyev V.V., Merkulova T.I. New elements of
glucocorticoid-receptor
binding sites of hormone-regulated genes. Biochim.
Biophys.
Acta 1991, v. 1089, p.367-376.
*Rogozin
I.B., Solovyev V.V., Kolchanov N.A. Somatic hypermutage- nesis in
immunoglobulin
genes. Correlation between somatic mu- tations and repeats.
Somatic
mutation properties and clonal se- lection. Biochim. Biophys. Acta
1991,
v.1089, p.175-182.
*Solovyev
V.V., Seledtsov I.A. A new approach to the phylogenetic trees
reconstruction
based on the analysis of relatively con- cervative regions
of
nucleotide and aminoacid sequences. Proc. Acad. Sci. Russia, (Russ)
(Genetics)1991,
321, 1109-1114.
*Solovyev
V.V. Graphic methods of representation and analysis of the DNA
and
protein sequeences. 1991, The Institute of Cytology and genetics USSR
Acad.Sci.,
Novosibirsk, 98 p.
*Solovyev
V.V., Korolev S.V., V.G. Tumanyan, Lim H.A. (1991) A new
approach
to classification of DNA regions based on fractal representation
of
functionally similar sequences. Proc.Natl.Acad.Sci.of USSR
(Russ)(Biochemistry),1991,
319(6), 1496-1500.
*Potapov
V.A., Solovyev V.V., Romashenko A.G., Sosnovtsev S.V., Ivanov
S.V.
The structural and evolutional features of complex tandemly arranged
Bsp-repeats
in fox genome. 1. Tissue-specific and recombinational sites in
the
BamH1-dimer. Mol.biol., 1991, v.25, n 1, p.116-132 (Russ).
*Potapov
V.A., Solovyev V.V., Romashenko A.G., Sosnovtsev S.V., Ivanov
S.V.
The structural and evolutional features of complex tandemly arranged
Bsp-repeats
in fox genome. 1. Structure and internal organization of the
BamH1-dimer.
Mol.biol., 1990, v.24, n 6, p.1649-1665 (Russ).
*Solovyev
V.V., Salamov A.A. Method of calculation of discrete secondary
structures
of the globular proteins. Mol.biol., 1991, v.25, n 3, p.810-824
(Russ).
*Solovyev
V.V., Salamov A.A., Kapitonov V.V. Factors determi- ning
formation
of globular proteins secondary structures. Mol.biol., 1991, v.25,
n 3,
p.795-809 (Russ).
*Vershinin
A.V., Salina E.A., Solovyev V.V., Timofeyeva L.L. Genomic
organization,
evolution, and structural peculiarities of highly repetitive
DNA of
Hordeum vulgare. Genome,1990, v.33, p.441-449.
*Solovyev
V.V., Kell A.E. New methods for RNA secondary structure
calculation.
Search for global minimum and accoun- ting of folding.
Abstracts
of international conference "Modelling and computer methods in
molecular
biology and genetics", Novosibirsk, 1990, p.53-54.
*Solovyev
V.V., Salihova A.K., Rogozin I.B. The system of the functional
diagnostics
of the genetic texts. in Computer analysis of structure,
function
and evolution of genetic macromolecules, Novosibirsk,
Siberian.Brunch.of
the Acad.Sci.USSR, p. 12-40,(Russ)(1989).
*Seledtsov
I.A., Solovyev V.V.,Merculova T.I. The new elements in the
structure
of the glucocorticoid-receptor complex binding sites in
hormone-regulated
genes. Mol.Biol.24,716- 728,(Russ),(1990).
*Romashenko
A.G.,Potapov V.A.,Solovyev V.V. The distribution and
structural
and functional significance of the complicated repeated
sequences
of the DNA in the animals genomes. In Structural and functional
genome
organization. Novosibirsk, "Science" (Russ.) p.80-114,(1989).
*Kolchanov
N.A., Rogozin I.B., Solovyev V.V. Theoretical analysis of
mechanisms
of spontanious and indused mutations' emergence in DNA on the
basis
of repeated sequences. Genetics (Russ.),25,1690-1698,(1989).
*Solovyev
V.V., Kell A.E., Kolchanov N.A. The convergent origin of repeats
in
genes coding globular proteins. Analysis of factors determining the
presence
of inverted and symmetrical repeats. General
Biol.(Russ),L,116-122,
(1989).
*Kell
A.E., Kolchanov N.A.,Solovyev V.V. Statistical evi- dence of the
connection
between deletions of procaryotic DNA and direct repeats.
Mol.Biol.(Russ)
23,175-183,(1989).
*Kell
A.E., Kolchanov N.A., Solovyev V.V. Theoretical analysis of deletion
emergence
mechanisms in prokaryotic genomes on the basis of direct repeats.
Mol.Biol.(Russ)
23,184-191,(1989).
*Kolchanov
N.A., Solovyev V.V.,Kell A.E. Theoretical ana- lysis of DNA
duplication
mechanisms in the prokaryotic genomes on the basis of repeats.
Mol.Biol.(Russ),
23,537-544, (1989).
*Solovyev
V.V., Rogozin I.B., Kolchanov N.A. Somatic hyper- mutagenesis in
immunoglobulin
genes. 1.Connection of somatic mutations with repeats. The
method
of statistical weights. Mol.Biol.(Russ), 23,783-794, (1989).
*Rogozin
I.B., Solovyev V.V. The somatic hypermutagenesis in
immunoglobuline
genes. 2.The properties of the somatic muta- tions and
clonal
selection. Mol.Biol.(Russ),23,795-802, (1989).
*Kell
A.E., Kolchanov N.A.,Solovyev V.V. The convergent origin of repeats
in
globular protein genes. Analysis of factors determining the presence of
direct
repeats. General Biol.(Russ),XLIX,343-354,(1988).
*Kolchanov
N.A.,Kell A.E.,Solovyev V.V. The convergent origin of repeats
in
globular protein genes. Modeling of the convergent origin of direct
repeats.
General Biol. (Russ), XLIX,723-727,(1988).
*Potapov
V.A., Sosnovtsev S.V., Solovyev V.V., Ivanov S.V., Romashenko
A.G.,
Kolchanov V.A.The structure of the complex repeats precentromere
geterochromatine
of the fox: elements of the control of the
replication,recombination
and gene expression. Proceedings of the USSR
Acad.Sci.,
(Russ), 229,1250-1285, (1988).
*Kolchanov
N.A., Solovyev V.V., Rogozin I.B. Peculiarities of
immunoglobulin
gene structure as a basis for somatic mutation emergence.
FEBS
Lett.,214,87-91,(1987).
*Kapitonov
V.B., Kolchanov N.A.,Shahmuradov I.A., Solovyev V.V. The
existence
of heat-shock regulatory sites in mobile genetic elements.
Genetics
(Russ.),28,2112-2119,(1987).
*Shahmuridov
K.A. Kolchanov N.A.Solovyev V.V.Ratner V.A. Enhancer-like
structures
in middle repetitive sequences of the eukaryotic genomes.
Genetics
(Russ),22, 357-368,(1986).
*Gorshkova
I.I. Zenkova M.A. Karkova G.G. Levina A.S. Solovyev V.V.
Complementary
adressed alkilation of 16 rRNA from E.coli with
2',3'-O-[4-N-(2-chloro-ethyl)-N-methilamino]
-bensilodene derivatives of
deoxiribooligonucleotides.
1.Kinetic parameters of alkylaton.
Mol.Biol.(Russ),
20, 1086-1099,(1986).
*Salganik
R.I.,Dianov G.L.,Medvedev O.A.,Solovyev V.V. The claster of the
point
mutations predetermined by the quasypalindromic sequences of the
nucleotide
in the DNA. Proceedings of the USSR Academy of Science (Russ),
291,1499-1502,(1986).
*Solovyev
V.V.,Rogozin I.B. The program package of the context analysis of
DNA,
RNA and protein sequenses 1.Search for gomology and functional sites.
Institute
Cytology and Genetics of the USSR Academy of Science,
Novosibirsk,(Russ),1-70,(1986).
*Kell
A.E.,Kolchanov N.A.,Solovyev V.V. Molecular mechanism of the
promotors
functioning on the base of the imperfect repeats. In Theoretical
research
and data banks in Molecular Biology and genetics. Novosibirsk,
127-130,(Russ)(1986).
*Solovyev
V.V.The system of visualisation and comparison of biological
macromolecule
tertiary structures "SVIS". In Theoretical research and data
banks
in Mol.Biol. and genetics.,127-130, Novosibirsk,(Russ),(1986)
*Solovyev
V.V.,Zharkikh A.A., Kolchanov N.A. A method of contextual
analysis
of the polynucleotide sequenses.1. The direct repeats within gene
regions
of b-,b'-,s-subunits of Escherichia coli RNA polymerase. Mol.Biol.,
(Russ)
19,524-536 (1985).
*Kolchanov
N.A.,Solovyev V.V,Rogozin I.B. Molecular mechanism of the
somatic
hypermutagenesis in immunoglobulin genes. Proceedings of the USSR
Academy
of Science.,(Biochemistry) (Russ) 281,994-999,(1985).
*Solovyev
V.V, Kolchanav N.A. The eukaryotic genes exon-intron structure
can be
determined by the nucleosomes organisation of the chromatine and
related
peculiarities of gene expres- sion regulation. Proceedings of the
USSR
Academy of Science, (Biochemistry)(Russ) 284,232-237,(1985).
*Solovyev
V.V, Kolchanov N.A. Functional and evolutionary role of the
eucaryotic
genes exon-intron structure. in VINITI re- view,
Mol.Biol.(Russ),
v. 21, 38-79,(1985).
*Solovyev
V.V,Zharkikh A.A,Kolchanov N.A. The template RNAs of RNA
polymerases
can have compact secondary structure formed by long double
helices
with partial violation of the complementaraty. FEBS Lett.,
165,72-78,(1984).
*Solovyev
V.V., Kolchanov N.A. A simple method for the calculation of low
energy
packings of a-helices.A threshold Approximation. 1. The use of the
method
to estimate the effects of amino acid substitutions , deletions ,
and
insertions in globin. J.theor.Biol., 110, 67-91,(1984)
*Zharkikh
A.A, Solovyev V.V., Kolchanov N.A. Conformational changings in
the
Globin Family during Evolution 1. Analysis of the Evolutionary Role of
Insertions
and Deletions. J.Mol.Evol.,21,42-53,(1984).
*Kolchanov
N.A.,Solovyev V.V.,Zharkikch A.A. High saturation of the direct
repeats
within gene RNA-polymerase on the base of the context analysis.
Proceedings
of USSR Academy of Science (Biochemistry), (Russ)
273,741-744,(1983)
*Kolchanov
N.A.,Solovyev V.V.,Zharkikh A.A. The effect of mutation
deletion
and insertion of single amino acids on the three-dimensional
structure
of globins. FEBS Lett.,161,65-70, (1983).
*Solovyev
V.V.,Kolchanov N.A. A method for the calculation of low energy
conformations
of the pair of helices in the globular proteins. Mol.Biol.
(Russ)
15, 323-335 (1981).
*Solovyev
V.V.,Kolchanov N.A. Single amino acid substitution can lead to
the
complete distortion of a normal 3D structure of globular
proteins.
Genetics (Russ) 18, 1573-1580 (1982).
Educational
books for university students:
+ Solovyev V.V., Kell A.E., Rogozin I.B.,
Kolchanov N.A. The application
of computers in Molecular Biology. The
theory of genetic texts.
Novosibirsk State University (Russ),90
p.,(1987).
+ Kolchanov N.A.,Solovyev V.V.,Shindyalov
I.N.,Strelets V.B. The
application of computers in Molecular
Biology. The structural
organization of globular proteins.
Novosibirsk State University
(Russ),(1986),90 p.
+ Kell A.E., Kolchanov N.A.,Solovyev
V.V.The mathematical modeling in
the molecular biology and genetics. The
theory of the mutational
process: deletions and duplications.
Novosibirsk State University
(1989),90 p.