Professor Victor Solovyev



   + Work Address:

Department of Computer Science, Royal Holloway, University of London,
Egham, Surrey TW20 0EX,

United Kingdom

   + Telephone: +44 (0)1784 443673 FAX: +44 (0) 1784 439786

   + Email:( 


   Expert in computational biology and leading author of widely used bioinformatics software. I worked as Genome annotation Group Leader in Joint Genomic Institute, Lawrence Berkeley National Lab (2003) and a consultant to several biotechnology/bioinformatics companies as well as Director of Bioinformatics at EOS Biotechnology (1999-2002) and leader of Computational Genomics Group at the Sanger Centre, Cambridge, UK (1997-1999). He also held positions of assistant professor at Baylor College of Medicine, computational scientist at Amgen, visiting scientist at Supercomputer Center, Florida State University, visiting professor at ITBA (Milan, Italy) and group leader at Institute of Cytology and Genetics, Novosibirsk, Russia. Dr. Solovyev received Ph.D. in computational genetics from Russian Academy of Sciences in 1985 and M.S. in physics from Novosibirsk State University in 1978.


Area of Scientific terest: Computational Biology

Developing computational methods of statistical analysis of bio-medical data including sequences and structures to discover non-random patterns responsible for their functions: prediction of promoters and splice sites using discriminant analysis, finding bacterial and eukaryotic genes by Hidden Markov Models, fast comparison of genomes, prediction of protein sub-cellular localization using neural networks approaches; fold recognition, modeling protein structure and protein-ligand docking; statistical analysis of expression data with finding disease specific genes; discovery and finding transcription regulation motifs and regulatory networks, developing databases of genomic information, building software pipelines of high-throughput computational analysis of bio-medical data; developing software to support new sequencing technologies (Solexa sequencing machine), SNP detection and transcriptome analysis (with RNASeq data). Application of bioinformatics approaches to potential drug targets discovery, modeling drug response and genetic networks gaining insights into the static and dynamic behavior of complex biological systems.

Member of the Board/Editor of Mathematical Biosciences journal (2008 ¿present)

The leading author/coauthor of the WWW servers programs:


The Sanger Centre, Baylor College of Medicine and Softberry Inc. Genefinder services:

   * Fgenesh++ - automatic eukaryotic genome annotation pipeline with
   * Fgenesb_annotator - pipeline to annotate new bacterial sequences
     with genes, operons, promoter and terminator predictions.
   * SELTAG - analysis of EXPRESSION DATA to select drug targets for 
     disease specific genes
   * GenomeExplorer - visualization and interactive work with genome annotation
   * FGENESH - HMM based prediction of multiple genes in genomic DNA
   * BESTORF - prediction of coding regions and ORFs in mRNA/cDNA/EST sequences
   * FGENEH+ - search for Human gene structure with using similar protein
   * FGENEH_C - search for Human gene structure with using similar EST/cDNA
   * SPL - splice sites identification in genomic sequences
   * TSSG/W - recognition of human promoter regions
   * SSPAL - prediction of secondary structure using local alignments
   * ProtComp - identification of Protein sub-cellular location
   * FOLD - recognition of protein fold by using 3D environment characteristics 
   * SCAN2 - comparison long genomic sequences
   * DBSCAN - comparison genomic sequence with a database of genomic sequences
   * EST_MAP - fast mapping a SET of mRNA/EST on chromosome sequence
   * Prot_MAP - fast mapping a SET of proteins on chromosome sequence
   * OligoZip - sequence assembling tools for new generation sequencing 
   * Transomics ¿ pipeline to map RNAseq data, assemble them into transcripts 
     and quantify the abundance of these transcripts in particular datasets
   * MolQuest - Bioinformatics Toolbox for analysis of biomedical data

Ph.D. Supervised:

   * 1. Rogozin I.B. " Theoretical analysis of the mechanisms of

     spontanious and indused mutations" Institute Cytology and genetics,

     Novosibirsk, 1990.

   * 2. Salamov A.A. "Computer system for investigation of globular protein

     secondary structure", Institute Cytology and Genetics,



Author of more than 100 scientific publications, including 8 monographs,

several books for university students and the following main publications:




   * Solovyev V.V., Salikhova A.K., Lim H.A. Tertiary structure calculations

     of a-helical domains of protein molecules using the quasispherical

     primary approximations. In Biomedical Modeling and Simulation

     (J.Eisenfeld, D.Levin, M.Witten Eds.) 1992, Elsevier Science

     Publishers B.V. (North-Holland), p.201-211.

   * Ratner V.A.,Zharkikh A.A,Kolchanov N.A.,Rodin S.N.,Solovyev V.V.

     Shamin V.V. Problems of the theory of molecular evolution. ( R.I.

     Salganik ed.) "Science",Siberian Branch of the USSR Academy of

     Science, Novosibirsk, (Russ) 259 p. (1985).

   * Solovyev V.V. Analysis of functional sites in pro- and eukaryotic

     genes. In "Methods of molecular genetics and gene engineering" ( R.I.

     Salganik ed.) "Science", Novosibirsk, (Russ.) 154-190, (1990).

   * Solovyev V.V et al., 12 paragraphs In Computer analysis of Genetic

     Macromolecules. Structure, Function and Evolution. (eds. Kolchanov

     N.A., Lim H.A.), 1994, World Scientific, 556 p.

   * Ratner V.A.,Zharkikh A.A,Kolchanov N.A.,Rodin S.N.,Solovyev V.V.,

     Antonoc A.S. Molecular evolution. Biomathematics, V 24, Springer,

     1996, p.433.

   # Solovyev V.V. (2002) Structure, Properties and Computer Identification of

     Eukaryotic genes. In Bioinformatics from Genomes to Drugs. V.1. Basic

     Technologies. (ed. Lengauer T.), p. 59 - 111.

# Solovyev V.V., Shindyalov I.N. (2002) Properties and Prediction of Protein

  Secondary Structure. In Current Topics in Computational Biology (eds.

  T.Jiang, T. Smith, Y. Xu, M. Zhang), in The MIT Press, p. 201 – 248.

# Solovyev V.V. (2002) Finding genes by computer: probabilistic and

  discriminative approaches. In Current Topics in Computational Biology (eds.

  T.Jiang, T. Smith, Y. Xu, M. Zhang), in The MIT Press, p. 365-401.


Selected Articles:


The Nasonia Genome Working Group, et al. (2010) Functional and Evolutionary Insights 
from the Genomes of Three Parasitoid Nasonia Species. Science 327, 343-348.
The Bovine Genome Sequencing and Analysis Consortium. (2009) The Genome sequence of 
taurine cattle: A window to ruminant biology and evolution. Science, 324, 522-528.
Mayako Michino et al., (2009) Community-wide assessment of GPCR structure modelling 
and ligand docking. Nature Reviews Drug Discovery 8, 455-463.

Coghlan A. et al. (2008) nGASP - the nematode genome annotation assessment project. 
BMC Bioinformatics 2008, 9:549.
Richards S.  et al., (2008) The genome of the model beetle and pest Tribolium castaneum.
Nature. 452 (7190), 949-55.

Velasco R. et al (2007) A High Quality Draft Consensus Sequence of the Genome of a
Heterozygous Grapevine Variety. PLoS ONE 2(12): e1326.

Solovyev V.V. (2007) Statistical approaches in Eukaryotic gene prediction.
In Handbook of Statistical genetics (eds. Balding D., Cannings C., Bishop M.),
Wiley-Interscience; 3 edition, 1616 p.  

Weinstock et al. Insights into social insects from the genome of the honey bee Apis mellifer. Nature (2006) , 433, 7114, 931-949.

Solovyev V, Kosarev P, Seledsov I, Vorobyev D. Automatic annotation of eukaryotic genes, pseudogenes and promoters. Genome Biol. 2006,7, Suppl 1: P. 10.1-10.12.

Bajic VB, Brent MR, Brown RH, Frankish A, Harrow J, Ohler U, Solovyev VV, Tan SL. Performance assessment of promoter predictions on ENCODE regions in the EGASP experiment. Genome Biol. 2006, 7, Suppl 1, p. 3.1-3.13.

Shahmuradov I, V. V. Solovyev and A. J. Gammerman (2005) Plant promoter prediction with confidence estimation. Nucleic Acids Research 33(3):1069-1076.

Tyson, G.W., Chapman, J., Hugenholtz, P. , Allen, E. , Ram, R.J.*, Richardson, P., Solovyev, V., Rubin, E. , Rokhsar, D., and Banfield, J.F. (2004) Community structure and metabolism through reconstruction of microbial genomes from the environment. Nature, 428(6978), 37-43.


Grimwood J, Gordon LA, Olsen A, .., Solovyev V., ..., Lukas S. (2004) The DNA sequence and biology of human chromosome 19. Nature, 428(6982), 529-535.


Michael Brudno, Alexander Poliakov, Asaf Salamov3, Gregory M. Cooper, Arend Sidow, Edward M. Rubin2, Victor Solovyev, Serafim Batzoglou, Inna Dubchak (2004)  Automated Whole-Genome Multiple Alignment of Rat, Mouse, and Human. Genome Research, 14(4), 685-92.

Hild M, Beckmann B, Haas SA, Koch B, Solovyev V, Busold C, Fellenberg K, Boutros M, Vingron M, Sauer F, Hoheisel JD, Paro R. (2003) An integrated gene annotation and transcriptional profiling approach towards the full gene content of the Drosophila genome. Genome Biol., 5(1):R3. Epub 2003 Dec 22.


Shahmuradov IA, Akbarova YY, Solovyev VV, Aliyev JA. (2003) Abundance of

plastid DNA insertions in nuclear genomes of rice and Arabidopsis. Plant Mol Biol. 52(5): 923-934.


Gordon L, Chervonenkis AY, Gammerman AJ, Shahmuradov IA, Solovyev VV. (2003)

Sequence alignment kernel for recognition of promoter regions.
Bioinformatics. 19(15):1964-1971.


Solovyev VV, Shahmuradov IA. (2003) PromH: Promoters identification using orthologous genomic sequences. Nucleic Acids Res. 31(13):3540-3545.


Shahmuradov IA, Gammerman AJ, Hancock JM, Bramley PM, Solovyev VV. (2003) PlantProm: a database of plant promoter sequences. Nucleic Acids Res. 31(1): 114-117.


Schuller CM, Geier B, Fritz A, Salamov A, Seledsov I, Solovyev V, Frishman D. (2002) The pedant human genome database - functional annotation of the human genome. Scientific World Journal. 2 (1 Suppl 2): 82-83.


*Burset M., Seledtsov I., Solovyev V. (2001) SpliceDB: database of canonical

and non-canonical mammalian splice sites. Nucleic Acids Res., 29(1), 255-259.


*Salamov A., Solovyev V. (2000) Ab initio gene finding in Drosophila

genomic DNA. Genome Res. 10(4), 516-522.


*Burset M., Seledtsov I., Solovyev V. (2000) Analysis of canonical and non-canonical

splice sites in mammalian genomes. Nucleic Acids Res., 28(21), 4364-4375.


Filippov V., Solovyev V., Filippova M., Gill S. (2000) A novel type of RNase

III family proteins in eukaryotes. Gene, 245(1), 213-221.


*Kolchanov NA, Ponomarenko MP, Frolov AS, Ananko EA, Kolpakov FA,

Ignatieva EV, Podkolodnaya OA, Goryachkovskaya TN, Stepanenko IL, Merkulova

TI, Babenko VV, Ponomarenko YV, Kochetov AV, Podkolodny NL, Vorobiev DV,

Lavryushev SV, Grigorovich DA, Kondrakhin YV, Milanesi L, Wingender E,

Solovyev V, Overton GC (1999) Integrated databases and computer systems for

studying eukaryotic gene expression. Bioinformatics, 15(7-8):669-86


*Solovyev V.V., Salamov A.A. (1999) INFOGENE: a database of known gene

structures and predicted genes and proteins in sequences of genome

sequencing projects. Nucl.Acid Res., 27,248-250.


*Alexandrov N.N., Solovyev V.V.(1998) Statistical significance of ungapped

sequence alignment. In Pacific Symposium on Biocomputing'98 (eds. Altman

R.,Dunker K.,Hunter L., Klein T.), p.463-472.


*Kolchanov N.A. et al. (1998) GeneExpress: a computer system for

description, analysis, and recognition of regulatory sequences in

eukaryotic genome. In Proceedings of the Sixth International Conference on

Intelligent Systems for Molecular Biology (eds.Gaasterland T. et



*Agulnik A.I.,Bishop C.E., Lerner J.L., Agulnik S.I., Solovyev V.V.(1977)

Analysis of mutation rate in the SMCY/SMCX genes shows that mammalian

evolution is male driven. Mammalian Genome 8, 134-138.


*Salamov A.A., Solovyev V.V. (1997) Protein secondary sturcture prediction

using local alignments. J. Mol.Biol,268,1, 31-36..


*Solovyev V.V., Salamov A.A. (1997) The Gene-Finder computer tools for

analysis of human and model organisms genome sequences. In Proceedings of

the Fifth International Conference on Intelligent Systems for Molecular

Biology (eds.Rawling C.,Clark D.,Altman R.,Hunter L., Lengauer T.,Wodak

S.), Halkidiki, Greece, AAAI Press,294-302.


*Salamov A.A., Solovyev V.V. (1997) Recognition of 3'-end cleavage and

polyadenilation region of human mRNA precursors. CABIOS 13, 1, 23-28.


*Alexandrov N., Solovyev V. (1996) Effect of Secondary Structure

Prediction on Protein Fold Recognition and Database Search. The Seventh

Workshop on Genome Informatics (GIW96), Tokyo, Japan.


*Kelly R.L., Solovyeva I., Lyman L.M., Richman R., Solovyev V.V., Kuroda

M. (1995) Expression of MSL-2 causes assembly of dosage compensation

regulators on the X chromosomes and female lethality in Drosophila.



*Solovyev V.V., Salamov A.A., Lawrence C.B. (1995) Prediction of human

gene structure using linear discriminant functions and dynamic programming.

In Proceedings of the Third International Conference on Intelligent Systems

for Molecular Biology (eds. Rawling C.,Clark D.,Altman R.,Hunter

L.,Lengauer T.,Wodak S.), Cambridge,England, AAAI Press,367-375.


*Salamov A.A., Solovyev V.V. Prediction of protein secondary structure by

combining nearest-neighbor algorithms and multiple sequence alignments. J.

Mol.Biol. (1995), 247,1,11-15.


*Solovyev V.V., Salamov A.A. Predicting a-helix and b-strand segments of

globular proteins. CABIOS (1994),v.10,6,661-669.


*Solovyev V.V., Salamov A.A., Lawrence C.B. Predicting internal exons by

oligonucleotide composition and discriminant analysis of spliceable open

reading frames. Nucl. Acids Res. (1994) 22,N 24,5156-5163.


*Solovyev V.V., Salamov A.A., Lawrence C.B. 1994. The prediction of human

exons by oligonucleotide composition and discriminant analysis of

spliceable open reading frames. In Proceedings of the Second International

Conference on Intelligent Systems for Molecular Biology (eds. Altman

R.,Brutlag D.,Karp P.,Lathrop R.,Searls D.), Stanford,CA, 354-362.


*Lawrence C.B., Solovyev V.V. Assignment of Position-Specific Error

Probability to primary DNA Sequence Data. Nucl.Acids Res., 1994, 22,



*Solovyev,V., Lawrence,C.B. Prediction of human gene structure using

dynamic programming and oligonucleotide composition. In: Abstracts of the

4th annual Keck symposium. Pittsburgh, 47,1993.


*Solovyev V.V., Streletc V.B., Milanesi L. (1993) Multiple sequence

alignment based on new approaches of tree construction and sequences

comparison. Proceedings of the 2-nd International conference on

Bioinformatics, Supercomputing, and Complex genome analysis. (eds. Lim H.,

Fickett J., Cantor C., Robbins R.), World Scientific, 419-428.

*Solovyev V.V. Fractal graphical representation and analysis of DNA and

Protein sequences. BioSystems, 30, (1993), 137-160.

*Solovyev V.V., Lawrence C.B. (1993) Identification of Human gene

functional regions based on oligonucleotide composition. In Proceedings of

First International conference on Intelligent System for Molecular Biology

(eds. Hunter L., Searls D., Shalvic J.), Bethesda, 371-379.

*Solovyev V.V., Makarova K.S. A novel method of protein sequences

classification based on oligopeptide frequency analysis and its application

to search for functional sites and to domain localization. CABIOS 1993,


*Makarova K.S., Mazin A.V., Wolf Y.I., Solovyev V.V. "DIROM"- an

experimental design interactive system for directed muta- genesis and

nucleic acids engineering. CABIOS 1992,8,425-431.

*Solovyev V.V., Korolev S.V., Lim H.A. A new approach for the

classification of functional regions of DNA sequences based on fractal

representation. 1993, Int.J. Genomic. Res.,1,2, 108-127.

*Seledtsov I.A., Solovyev V.V., Merkulova T.I. New elements of

glucocorticoid-receptor binding sites of hormone-regulated genes. Biochim.

Biophys. Acta 1991, v. 1089, p.367-376.

*Rogozin I.B., Solovyev V.V., Kolchanov N.A. Somatic hypermutage- nesis in

immunoglobulin genes. Correlation between somatic mu- tations and repeats.

Somatic mutation properties and clonal se- lection. Biochim. Biophys. Acta

1991, v.1089, p.175-182.

*Solovyev V.V., Seledtsov I.A. A new approach to the phylogenetic trees

reconstruction based on the analysis of relatively con- cervative regions

of nucleotide and aminoacid sequences. Proc. Acad. Sci. Russia, (Russ)

(Genetics)1991, 321, 1109-1114.

*Solovyev V.V. Graphic methods of representation and analysis of the DNA

and protein sequeences. 1991, The Institute of Cytology and genetics USSR

Acad.Sci., Novosibirsk, 98 p.

*Solovyev V.V., Korolev S.V., V.G. Tumanyan, Lim H.A. (1991) A new

approach to classification of DNA regions based on fractal representation

of functionally similar sequences. Proc.Natl.Acad.Sci.of USSR

(Russ)(Biochemistry),1991, 319(6), 1496-1500.

*Potapov V.A., Solovyev V.V., Romashenko A.G., Sosnovtsev S.V., Ivanov

S.V. The structural and evolutional features of complex tandemly arranged

Bsp-repeats in fox genome. 1. Tissue-specific and recombinational sites in

the BamH1-dimer. Mol.biol., 1991, v.25, n 1, p.116-132 (Russ).

*Potapov V.A., Solovyev V.V., Romashenko A.G., Sosnovtsev S.V., Ivanov

S.V. The structural and evolutional features of complex tandemly arranged

Bsp-repeats in fox genome. 1. Structure and internal organization of the

BamH1-dimer. Mol.biol., 1990, v.24, n 6, p.1649-1665 (Russ).

*Solovyev V.V., Salamov A.A. Method of calculation of discrete secondary

structures of the globular proteins. Mol.biol., 1991, v.25, n 3, p.810-824


*Solovyev V.V., Salamov A.A., Kapitonov V.V. Factors determi- ning

formation of globular proteins secondary structures. Mol.biol., 1991, v.25,

n 3, p.795-809 (Russ).

*Vershinin A.V., Salina E.A., Solovyev V.V., Timofeyeva L.L. Genomic

organization, evolution, and structural peculiarities of highly repetitive

DNA of Hordeum vulgare. Genome,1990, v.33, p.441-449.

*Solovyev V.V., Kell A.E. New methods for RNA secondary structure

calculation. Search for global minimum and accoun- ting of folding.

Abstracts of international conference "Modelling and computer methods in

molecular biology and genetics", Novosibirsk, 1990, p.53-54.

*Solovyev V.V., Salihova A.K., Rogozin I.B. The system of the functional

diagnostics of the genetic texts. in Computer analysis of structure,

function and evolution of genetic macromolecules, Novosibirsk,

Siberian.Brunch.of the Acad.Sci.USSR, p. 12-40,(Russ)(1989).

*Seledtsov I.A., Solovyev V.V.,Merculova T.I. The new elements in the

structure of the glucocorticoid-receptor complex binding sites in

hormone-regulated genes. Mol.Biol.24,716- 728,(Russ),(1990).

*Romashenko A.G.,Potapov V.A.,Solovyev V.V. The distribution and

structural and functional significance of the complicated repeated

sequences of the DNA in the animals genomes. In Structural and functional

genome organization. Novosibirsk, "Science" (Russ.) p.80-114,(1989).

*Kolchanov N.A., Rogozin I.B., Solovyev V.V. Theoretical analysis of

mechanisms of spontanious and indused mutations' emergence in DNA on the

basis of repeated sequences. Genetics (Russ.),25,1690-1698,(1989).

*Solovyev V.V., Kell A.E., Kolchanov N.A. The convergent origin of repeats

in genes coding globular proteins. Analysis of factors determining the

presence of inverted and symmetrical repeats. General

Biol.(Russ),L,116-122, (1989).

*Kell A.E., Kolchanov N.A.,Solovyev V.V. Statistical evi- dence of the

connection between deletions of procaryotic DNA and direct repeats.

Mol.Biol.(Russ) 23,175-183,(1989).

*Kell A.E., Kolchanov N.A., Solovyev V.V. Theoretical analysis of deletion

emergence mechanisms in prokaryotic genomes on the basis of direct repeats.

Mol.Biol.(Russ) 23,184-191,(1989).

*Kolchanov N.A., Solovyev V.V.,Kell A.E. Theoretical ana- lysis of DNA

duplication mechanisms in the prokaryotic genomes on the basis of repeats.

Mol.Biol.(Russ), 23,537-544, (1989).

*Solovyev V.V., Rogozin I.B., Kolchanov N.A. Somatic hyper- mutagenesis in

immunoglobulin genes. 1.Connection of somatic mutations with repeats. The

method of statistical weights. Mol.Biol.(Russ), 23,783-794, (1989).

*Rogozin I.B., Solovyev V.V. The somatic hypermutagenesis in

immunoglobuline genes. 2.The properties of the somatic muta- tions and

clonal selection. Mol.Biol.(Russ),23,795-802, (1989).

*Kell A.E., Kolchanov N.A.,Solovyev V.V. The convergent origin of repeats

in globular protein genes. Analysis of factors determining the presence of

direct repeats. General Biol.(Russ),XLIX,343-354,(1988).

*Kolchanov N.A.,Kell A.E.,Solovyev V.V. The convergent origin of repeats

in globular protein genes. Modeling of the convergent origin of direct

repeats. General Biol. (Russ), XLIX,723-727,(1988).

*Potapov V.A., Sosnovtsev S.V., Solovyev V.V., Ivanov S.V., Romashenko

A.G., Kolchanov V.A.The structure of the complex repeats precentromere

geterochromatine of the fox: elements of the control of the

replication,recombination and gene expression. Proceedings of the USSR

Acad.Sci., (Russ), 229,1250-1285, (1988).

*Kolchanov N.A., Solovyev V.V., Rogozin I.B. Peculiarities of

immunoglobulin gene structure as a basis for somatic mutation emergence.

FEBS Lett.,214,87-91,(1987).

*Kapitonov V.B., Kolchanov N.A.,Shahmuradov I.A., Solovyev V.V. The

existence of heat-shock regulatory sites in mobile genetic elements.

Genetics (Russ.),28,2112-2119,(1987).

*Shahmuridov K.A. Kolchanov N.A.Solovyev V.V.Ratner V.A. Enhancer-like

structures in middle repetitive sequences of the eukaryotic genomes.

Genetics (Russ),22, 357-368,(1986).

*Gorshkova I.I. Zenkova M.A. Karkova G.G. Levina A.S. Solovyev V.V.

Complementary adressed alkilation of 16 rRNA from E.coli with

2',3'-O-[4-N-(2-chloro-ethyl)-N-methilamino] -bensilodene derivatives of

deoxiribooligonucleotides. 1.Kinetic parameters of alkylaton.

Mol.Biol.(Russ), 20, 1086-1099,(1986).

*Salganik R.I.,Dianov G.L.,Medvedev O.A.,Solovyev V.V. The claster of the

point mutations predetermined by the quasypalindromic sequences of the

nucleotide in the DNA. Proceedings of the USSR Academy of Science (Russ),


*Solovyev V.V.,Rogozin I.B. The program package of the context analysis of

DNA, RNA and protein sequenses 1.Search for gomology and functional sites.

Institute Cytology and Genetics of the USSR Academy of Science,


*Kell A.E.,Kolchanov N.A.,Solovyev V.V. Molecular mechanism of the

promotors functioning on the base of the imperfect repeats. In Theoretical

research and data banks in Molecular Biology and genetics. Novosibirsk,


*Solovyev V.V.The system of visualisation and comparison of biological

macromolecule tertiary structures "SVIS". In Theoretical research and data

banks in Mol.Biol. and genetics.,127-130, Novosibirsk,(Russ),(1986)

*Solovyev V.V.,Zharkikh A.A., Kolchanov N.A. A method of contextual

analysis of the polynucleotide sequenses.1. The direct repeats within gene

regions of b-,b'-,s-subunits of Escherichia coli RNA polymerase. Mol.Biol.,

(Russ) 19,524-536 (1985).

*Kolchanov N.A.,Solovyev V.V,Rogozin I.B. Molecular mechanism of the

somatic hypermutagenesis in immunoglobulin genes. Proceedings of the USSR

Academy of Science.,(Biochemistry) (Russ) 281,994-999,(1985).

*Solovyev V.V, Kolchanav N.A. The eukaryotic genes exon-intron structure

can be determined by the nucleosomes organisation of the chromatine and

related peculiarities of gene expres- sion regulation. Proceedings of the

USSR Academy of Science, (Biochemistry)(Russ) 284,232-237,(1985).

*Solovyev V.V, Kolchanov N.A. Functional and evolutionary role of the

eucaryotic genes exon-intron structure. in VINITI re- view,

Mol.Biol.(Russ), v. 21, 38-79,(1985).

*Solovyev V.V,Zharkikh A.A,Kolchanov N.A. The template RNAs of RNA

polymerases can have compact secondary structure formed by long double

helices with partial violation of the complementaraty. FEBS Lett.,


*Solovyev V.V., Kolchanov N.A. A simple method for the calculation of low

energy packings of a-helices.A threshold Approximation. 1. The use of the

method to estimate the effects of amino acid substitutions , deletions ,

and insertions in globin. J.theor.Biol., 110, 67-91,(1984)

*Zharkikh A.A, Solovyev V.V., Kolchanov N.A. Conformational changings in

the Globin Family during Evolution 1. Analysis of the Evolutionary Role of

Insertions and Deletions. J.Mol.Evol.,21,42-53,(1984).

*Kolchanov N.A.,Solovyev V.V.,Zharkikch A.A. High saturation of the direct

repeats within gene RNA-polymerase on the base of the context analysis.

Proceedings of USSR Academy of Science (Biochemistry), (Russ)


*Kolchanov N.A.,Solovyev V.V.,Zharkikh A.A. The effect of mutation

deletion and insertion of single amino acids on the three-dimensional

structure of globins. FEBS Lett.,161,65-70, (1983).

*Solovyev V.V.,Kolchanov N.A. A method for the calculation of low energy

conformations of the pair of helices in the globular proteins. Mol.Biol.

(Russ) 15, 323-335 (1981).

*Solovyev V.V.,Kolchanov N.A. Single amino acid substitution can lead to

the complete distortion of a normal 3D structure of globular

proteins. Genetics (Russ) 18, 1573-1580 (1982).


Educational books for university students:


   + Solovyev V.V., Kell A.E., Rogozin I.B., Kolchanov N.A. The application

     of computers in Molecular Biology. The theory of genetic texts.

     Novosibirsk State University (Russ),90 p.,(1987).

   + Kolchanov N.A.,Solovyev V.V.,Shindyalov I.N.,Strelets V.B. The

     application of computers in Molecular Biology. The structural

     organization of globular proteins. Novosibirsk State University

     (Russ),(1986),90 p.

   + Kell A.E., Kolchanov N.A.,Solovyev V.V.The mathematical modeling in

     the molecular biology and genetics. The theory of the mutational

     process: deletions and duplications. Novosibirsk State University

     (1989),90 p.