COMPUTER-ASSISTED FUNCTIONAL ANNOTATION OF DNA SEQUENCES
Professor M Gelfand, State Scientific Center for Biotechnology GosNIIGenetika, Moscow, Russia

Abstract: The DNA data are generated at a very fast rate, clearly exceeding the capacity of experimental analysis. This makes it neccessary to develop methods for computer annotation of DNA. On the other hand, availability of complete genomes makes it possible to apply comparative techniques sharply increasing the reliability of individual predictions. I will first introduce the main biological notions, and thendescribe some recently developed approaches to recognition of regulatory sites. If time permits, I will also cover the problem of gene recognition. I do not plan to provide detailed descriptions of algorithms, but will try to describe the main ideas behind these algorithms and present some unsolved problems.

This seminar was held at the Department of Computer Science, Royal Holloway, University of London on 6 December, 1999.

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