Probabilistic Models of Sequence Evolution and Alignment
Dr Graeme Mitchison, MRC Laboratory for Molecular Biology, Cambridge

Abstract: Aligning protein and DNA sequences is a basic problem in molecular biology, and most successful methods use some statistical assumptions about the evolution of sequences. However, it has proved difficult to construct an adequate probabilistic model of sequence evolution. I describe a new approach to this problem.

Graeme Mitchison is at the MRC Laboratory for Molecular Biology in Cambridge, and he is one of the authors of a recent book "Biological Sequence Analysis: probabilistic models of proteins and nucleic acids" published by Cambridge University Press.

This seminar was held at the Department of Computer Science, Royal Holloway, University of London on 10 September 1998.

back